Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: A systematic review and meta-analysis

•Sleep disturbance is common in older adults, especially those with mild cognitive impairment and dementia.•Non-pharmacological interventions are either single-component or multi-component.•Bright-light therapy is the most extensively investigated intervention.•Meta-analysis showed that multi-domain...

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Veröffentlicht in:Maturitas 2019-09, Vol.127, p.82-94
Hauptverfasser: O’Caoimh, Rónán, Mannion, Helen, Sezgin, Duygu, O’Donovan, Mark R., Liew, Aaron, Molloy, D. William
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Sprache:eng
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Zusammenfassung:•Sleep disturbance is common in older adults, especially those with mild cognitive impairment and dementia.•Non-pharmacological interventions are either single-component or multi-component.•Bright-light therapy is the most extensively investigated intervention.•Meta-analysis showed that multi-domain interventions significantly improve sleepefficiency.•Studies were heterogeneous with no other significant results. No disease-modifying treatments for dementia are available. Sleep disturbance is strongly associated with cognitive impairment. Non-pharmacological treatments targeting sleep may offer an alternative therapeutic approach. We searched PubMed, CINAHL, EMBASE and the Cochrane library for non-pharmacological treatments for sleep disturbance in mild cognitive impairment (MCI) and dementia, published in English from October 1965 to 2018, including all designs, excluding studies of drug therapies. In all, 53 papers representing 48 studies were included. Participant age ranged from 67.3 to 89.4 years. Most studies (79%) had small samples (
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2019.06.007