Correction of diabetes‐induced testicular dysfunction by a hydro‐methanol (60:40) extract of Curcuma amada rhizomes: A dose‐dependent study

Diabetes affects the reproductive system. This study was conducted to find out the potent dose of the hydro‐methanol 60:40 extract of Curcuma amada rhizomes for the management of diabetes‐induced testicular dysfunction in albino rats. The extract was administered at the doses of 10, 20, 40, and 80 mg/100 g body weight/day for 28 days. Oxidative stresses, reproductive parameters, histological, and gene expressions of the testicular tissue were assessed. Out of the doses used, the 20‐mg dose showed maximum recovery as the minimum dose (e.g., sperm motility 112.03%, testicular cholesterol 34.86%, Bax gene expression 49.77%), whereas 40‐ and 80‐mg doses did not vary statistically with each other (e.g., sperm motility 95.37% and 89.19%, testicular cholesterol 30.42% and 28.41%, Bax gene expression 47.33% and 46.18%, respectively) as well as with the 20‐mg dose. It may be concluded that the 20‐mg dose is the threshold dose for this purpose. Practical applications The hydro‐methanol 60:40 extract of rhizomes of Curcuma amada has a strong antioxidant property that can manage diabetes‐induced oxidative injuries in testes which may raise a hope to the pharmaceutical industries to develop a herbal drug for diabetes‐linked testicular hypofunction management.