Changes in diet composition with urbanization and its effect on the polycystic ovarian syndrome phenotype in a Western Indian population

To study the effects of increasingly prosperous diet content on clinical features of polycystic ovary syndrome (PCOS). A cross-sectional cohort study of 711 women with PCOS from a heterogeneous population spanning a wide spectrum of socioeconomic strata. Independent hospital. A total of 711 women with PCOS in whom the diagnosis was based on Rotterdam criteria. Results were compared with a locally recruited reference group. Clinical assessment of women with PCOS. Clinical characteristics were assessed with particular reference to diet composition. Four diet groups were identified: simple rice with vegetables, vegetarian with mixed carbohydrates, nonvegetarian with mixed carbohydrates, and an urban diet of processed foods. Women with PCOS showed the characteristic features of raised LH and androstenedione concentrations and increased ovarian volume and antral follicle count. There was a notable association between an increasingly affluent diet, the presence of hirsutism, raised body mass index, insulin resistance, and higher serum antimüllerian hormone concentrations. The positive association between antimüllerian hormone and body mass index is an unusual feature possibly explained by the wide spectrum of lifestyles in this cohort. Urbanization of women in India is associated with increasingly severe phenotype of PCOS, which is likely to have implications on fertility outcomes. Cambio de la composición dietética con la urbanización y su efecto sobre el fenotipo del síndrome de ovario poliquístico en una población de india occidental Estudiar los efectos del contenido dietético en niveles incrementales de prosperidad sobre los rasgos clínicos del síndrome de ovario poliquístico (PCOS). Estudio transversal de cohortes de 711 mujeres con PCOS de una población heterogénea de amplio espectro socioeconómico. Hospital independiente. Un total de 711 mujeres con PCOS en quienes el diagnóstico se basó en los criterios de Rotterdam. Los resultados se compararon con un grupo local de referencia. Evaluación clínica de mujeres con PCOS. Las características clínicas se evaluaron haciendo referencia particularmente a la composición dietética. Se identificaron cuatro grupos dietéticos: arroz simple con verduras, vegetariano con carbohidratos mixtos, no-vegetariano con carbohidratos mixtos y dieta urbana de comidas procesadas. Las mujeres con PCOS mostraron los rasgos característicos de alta concentración de LH y androstenediona y alto volumen ovárico y número de folículos an