Polystyrene‐Supported Palladium (Pd@PS)‐Catalyzed Carbonylative Annulation of Aryl Iodides Using Oxalic Acid as a Sustainable CO Source for the Synthesis of 2‐Aryl Quinazolinones

An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o‐carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene supported palladium (Pd@PS) nanoparticles (NPs) catalyzed conditions has been developed. In this study, oxalic acid has been employed as safe, economic, environmentally benign, sustainable and bench‐stable, solid CO surrogate under Double‐Layer‐Vial (DLV) system for the synthesis of 2‐aryl quinazolinones. This methodology does not require any special high‐pressure equipment like autoclaves, microwaves, etc. Moreover, a simple procedure for catalyst preparation, catalyst recyclability, easy handling of reaction, additive and base‐free generation of CO, excellent to good yields and vast substrate scope are the additional features of developed protocol. Pd@PS for CO: An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o‐carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene‐supported palladium (Pd@PS) nanoparticles (NPs)‐catalyzed conditions has been developed. This protocol features simple procedure for catalyst preparation, catalyst recyclability, easy handling of reaction, additive and base‐free generation of CO as well as excellent to good yields and vast substrate scope