Bionanoelectronic platform with a lipid bilayer/CVD-grown MoS2 hybrid

We demonstrate a bionanoelectronic platform for a supported lipid bilayer formed on an MoS2 film for biosensing, biomolecule recognition, and bioelectronic applications. A large-area MoS2 film was synthesized on a sapphire substrate and treated with O2 plasma or Al2O3 deposition to change the surface from hydrophobic to hydrophilic. Measurements of fluorescence and fluorescence recovery after photobleaching confirmed the physical properties of the lipid bilayer on the treated surfaces. We fabricated an electronic device using the treated MoS2 film and characterized the influence of the lipid bilayer on its electrical properties. Furthermore, transmembrane ion channels peptide (gramicidin A) were incorporated into the lipid bilayer and modulations of the electrical properties of the device under various pH conditions and calcium ion were observed. This sensitive and stable platform has strong potential for housing artificial channels and transmembrane ion channels for advanced bioapplications. [Display omitted] •2D bionanoelectronics based on lipid/MoS2 hybrid was designed to monitor ion channel activity.•Integration of lipid bilayer on a MoS2 field effect transistor opens up potential utility of 2D nanomaterials for biosensing applications.•Hybrid structure of MoS2/lipid bilayer with membrane peptides can provide a platform for designing interface between biology and electronics.