Role of BCYRN1 in hepatocellular carcinoma pathogenesis by lncRNA-miRNA-mRNA network analysis and its diagnostic and prognostic value

This study aimed to excavate the roles of in hepatocellular carcinoma (HCC). A comprehensive strategy of microarray data mining, computational biology and experimental verification were adopted to assess the clinical significance of and identify related pathways. was upregulated in HCC and its expre...

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Veröffentlicht in:	Epigenomics 2019-08, Vol.11 (10), p.1209-1231
Hauptverfasser:	Ming, Xin-Liang, Feng, Yan-Lin, He, Ding-Dong, Luo, Chang-Liang, Rong, Jia-Ling, Zhang, Wu-Wen, Ye, Peng, Chai, Hong-Yan, Liang, Chun-Zi, Tu, Jian-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - genetics alpha-Fetoproteins - metabolism Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell growth Computational Biology Computer applications Data mining Diagnostic systems Female Females Follow-Up Studies Gene expression Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genomes Hepatitis Hepatocellular carcinoma Humans Infections Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metastases Metastasis MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA mRNA Natural history Network analysis Pathogenesis Patients Prognosis Program verification (computers) Protein Interaction Maps Proteins RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Survival Rate Transcriptome Tumorigenesis
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Zusammenfassung:	This study aimed to excavate the roles of in hepatocellular carcinoma (HCC). A comprehensive strategy of microarray data mining, computational biology and experimental verification were adopted to assess the clinical significance of and identify related pathways. was upregulated in HCC and its expression was positively associated with both tumor, node, metastasis and worse survival rate in patients with HCC. Through combing plasma with alpha fetoprotein, the diagnosis of HCC was remarkably improved. may regulate some cancer-related pathways to promote HCC initiation via an lncRNA-miRNA-mRNA network. Our results propose as a potential diagnostic and prognostic biomarker and offer a novel perspective to explore the etiopathogenesis of HCC.
ISSN:	1750-1911 1750-192X
DOI:	10.2217/epi-2018-0218