Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observatio...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-07, Vol.55 (60), p.8868-8871
Hauptverfasser: Pilkington, Lisa I, Deed, Rebecca C, Parish-Virtue, Katie, Huang, Chien-Wei, Walker, Michelle E, Jiranek, Vladimir, Barker, David, Fedrizzi, Bruno
Format: Artikel
Sprache:eng
Schlagworte:
Baking yeast
Hydrogen sulfide
Polysulfides
Yeast
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Zusammenfassung:New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc03020d