Comparative Study of Pulsed Versus Continuous High‐Intensity Focused Ultrasound Ablation Using In Vitro and In Vivo Models
Objectives To compare the efficacy of pulsed high‐intensity focused ultrasound (PHIFU) versus continuous high‐intensity focused ultrasound (CHIFU) ablation at identical doses. Methods Continuous and pulsed HIFU (1200 J) at duty cycles (DCs) of 60% and 20% were examined for their capacity to ablate b...
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| Veröffentlicht in: | Journal of ultrasound in medicine 2020-02, Vol.39 (2), p.259-271 |
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| creator | Wang, Yanhao Wang, Qi Luo, Yong Jiang, Lu Zeng, Zihuan Gan, Lidan Chen, Jianli Han, Hongfei Zou, Jianzhong |
| description | Objectives
To compare the efficacy of pulsed high‐intensity focused ultrasound (PHIFU) versus continuous high‐intensity focused ultrasound (CHIFU) ablation at identical doses.
Methods
Continuous and pulsed HIFU (1200 J) at duty cycles (DCs) of 60% and 20% were examined for their capacity to ablate bovine liver tissue in vitro and rabbit liver tissue in vivo. After ablation, grayscale changes and pathologic characteristics were observed or measured, and the tissue necrosis volume, energy efficiency factor, and average grayscale density were calculated.
Results
The pulsed mode generated greater liquefaction necrosis. An inconspicuous grayscale change was observed for PHIFU at a DC of 20% in some samples, which appeared as an elliptical cavity. The energy efficiency factor of PHIFU at a DC of 60% was significantly lower than that of CHIFU, as observed both in vitro and in vivo (P |
| doi_str_mv | 10.1002/jum.15098 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2263320113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2263320113</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3258-5803cb0256271a8f012fa71c436dc6fb5c5f97b804750f0ecef58414e73a5403</originalsourceid><addsrcrecordid>eNp1kMtOAyEUQInRaK0u_AHDUhdTeQzzWJpGbY1GE1u3E4YBxcxAhUHTxIWf4Df6JVKr7lwB4eTc3APAAUYjjBA5eQrdCDNUFhtggBlDSZlhugkGiORFkpIy3wG73j9FFOE83QY7FFNasrIcgLex7Rbc8V6_SHjXh2YJrYK3ofWygffS-eDh2Jpem2DjdaIfHj_fP6aml8brfgnPrQgrdN72jnsbTANP6zbqrIFzr80DnBp4r3tnIY9_348XC69tI1u_B7YUj5P2f84hmJ2fzcaT5OrmYjo-vUoEJaxIWIGoqBFhGckxLxTCRPEci5RmjchUzQRTZV4XKM0ZUkgKqViR4lTmlLMU0SE4WmsXzj4H6fuq017ItuVGxqUqQjJKY5oYZQiO16hw1nsnVbVwuuNuWWFUrVpXsXX13Tqyhz_aUHey-SN_40bgZA286lYu_zdVl_PrtfILxF6KNw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2263320113</pqid></control><display><type>article</type><title>Comparative Study of Pulsed Versus Continuous High‐Intensity Focused Ultrasound Ablation Using In Vitro and In Vivo Models</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wang, Yanhao ; Wang, Qi ; Luo, Yong ; Jiang, Lu ; Zeng, Zihuan ; Gan, Lidan ; Chen, Jianli ; Han, Hongfei ; Zou, Jianzhong</creator><creatorcontrib>Wang, Yanhao ; Wang, Qi ; Luo, Yong ; Jiang, Lu ; Zeng, Zihuan ; Gan, Lidan ; Chen, Jianli ; Han, Hongfei ; Zou, Jianzhong</creatorcontrib><description>Objectives
To compare the efficacy of pulsed high‐intensity focused ultrasound (PHIFU) versus continuous high‐intensity focused ultrasound (CHIFU) ablation at identical doses.
Methods
Continuous and pulsed HIFU (1200 J) at duty cycles (DCs) of 60% and 20% were examined for their capacity to ablate bovine liver tissue in vitro and rabbit liver tissue in vivo. After ablation, grayscale changes and pathologic characteristics were observed or measured, and the tissue necrosis volume, energy efficiency factor, and average grayscale density were calculated.
Results
The pulsed mode generated greater liquefaction necrosis. An inconspicuous grayscale change was observed for PHIFU at a DC of 20% in some samples, which appeared as an elliptical cavity. The energy efficiency factor of PHIFU at a DC of 60% was significantly lower than that of CHIFU, as observed both in vitro and in vivo (P < .05). The grayscale value and average grayscale density in response to CHIFU were significantly greater than those in response to PHIFU (60% or 20%; P < .05). Histopathologic analysis revealed liquefaction necrosis in all PHIFU groups.
Conclusions
At identical doses, compared with CHIFU, a single session of PHIFU can generate liquefaction necrosis and at a higher DC can improve ablation efficiency. This increased efficacy of PHIFU may involve enhancement of tissue destruction by cavitation effects and a reduction in the obstruction effect of endogenous microbubbles through cavitation effects or a more effective diffusion of heat.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.1002/jum.15098</identifier><identifier>PMID: 31339599</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>ablation ; comparison ; duty cycle ; high‐intensity focused ultrasound ; identical doses</subject><ispartof>Journal of ultrasound in medicine, 2020-02, Vol.39 (2), p.259-271</ispartof><rights>2019 by the American Institute of Ultrasound in Medicine</rights><rights>2019 by the American Institute of Ultrasound in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3258-5803cb0256271a8f012fa71c436dc6fb5c5f97b804750f0ecef58414e73a5403</citedby><cites>FETCH-LOGICAL-c3258-5803cb0256271a8f012fa71c436dc6fb5c5f97b804750f0ecef58414e73a5403</cites><orcidid>0000-0003-2500-0317</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjum.15098$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjum.15098$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31339599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yanhao</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Luo, Yong</creatorcontrib><creatorcontrib>Jiang, Lu</creatorcontrib><creatorcontrib>Zeng, Zihuan</creatorcontrib><creatorcontrib>Gan, Lidan</creatorcontrib><creatorcontrib>Chen, Jianli</creatorcontrib><creatorcontrib>Han, Hongfei</creatorcontrib><creatorcontrib>Zou, Jianzhong</creatorcontrib><title>Comparative Study of Pulsed Versus Continuous High‐Intensity Focused Ultrasound Ablation Using In Vitro and In Vivo Models</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>Objectives
To compare the efficacy of pulsed high‐intensity focused ultrasound (PHIFU) versus continuous high‐intensity focused ultrasound (CHIFU) ablation at identical doses.
Methods
Continuous and pulsed HIFU (1200 J) at duty cycles (DCs) of 60% and 20% were examined for their capacity to ablate bovine liver tissue in vitro and rabbit liver tissue in vivo. After ablation, grayscale changes and pathologic characteristics were observed or measured, and the tissue necrosis volume, energy efficiency factor, and average grayscale density were calculated.
Results
The pulsed mode generated greater liquefaction necrosis. An inconspicuous grayscale change was observed for PHIFU at a DC of 20% in some samples, which appeared as an elliptical cavity. The energy efficiency factor of PHIFU at a DC of 60% was significantly lower than that of CHIFU, as observed both in vitro and in vivo (P < .05). The grayscale value and average grayscale density in response to CHIFU were significantly greater than those in response to PHIFU (60% or 20%; P < .05). Histopathologic analysis revealed liquefaction necrosis in all PHIFU groups.
Conclusions
At identical doses, compared with CHIFU, a single session of PHIFU can generate liquefaction necrosis and at a higher DC can improve ablation efficiency. This increased efficacy of PHIFU may involve enhancement of tissue destruction by cavitation effects and a reduction in the obstruction effect of endogenous microbubbles through cavitation effects or a more effective diffusion of heat.</description><subject>ablation</subject><subject>comparison</subject><subject>duty cycle</subject><subject>high‐intensity focused ultrasound</subject><subject>identical doses</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOAyEUQInRaK0u_AHDUhdTeQzzWJpGbY1GE1u3E4YBxcxAhUHTxIWf4Df6JVKr7lwB4eTc3APAAUYjjBA5eQrdCDNUFhtggBlDSZlhugkGiORFkpIy3wG73j9FFOE83QY7FFNasrIcgLex7Rbc8V6_SHjXh2YJrYK3ofWygffS-eDh2Jpem2DjdaIfHj_fP6aml8brfgnPrQgrdN72jnsbTANP6zbqrIFzr80DnBp4r3tnIY9_348XC69tI1u_B7YUj5P2f84hmJ2fzcaT5OrmYjo-vUoEJaxIWIGoqBFhGckxLxTCRPEci5RmjchUzQRTZV4XKM0ZUkgKqViR4lTmlLMU0SE4WmsXzj4H6fuq017ItuVGxqUqQjJKY5oYZQiO16hw1nsnVbVwuuNuWWFUrVpXsXX13Tqyhz_aUHey-SN_40bgZA286lYu_zdVl_PrtfILxF6KNw</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Wang, Yanhao</creator><creator>Wang, Qi</creator><creator>Luo, Yong</creator><creator>Jiang, Lu</creator><creator>Zeng, Zihuan</creator><creator>Gan, Lidan</creator><creator>Chen, Jianli</creator><creator>Han, Hongfei</creator><creator>Zou, Jianzhong</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2500-0317</orcidid></search><sort><creationdate>202002</creationdate><title>Comparative Study of Pulsed Versus Continuous High‐Intensity Focused Ultrasound Ablation Using In Vitro and In Vivo Models</title><author>Wang, Yanhao ; Wang, Qi ; Luo, Yong ; Jiang, Lu ; Zeng, Zihuan ; Gan, Lidan ; Chen, Jianli ; Han, Hongfei ; Zou, Jianzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3258-5803cb0256271a8f012fa71c436dc6fb5c5f97b804750f0ecef58414e73a5403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ablation</topic><topic>comparison</topic><topic>duty cycle</topic><topic>high‐intensity focused ultrasound</topic><topic>identical doses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yanhao</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Luo, Yong</creatorcontrib><creatorcontrib>Jiang, Lu</creatorcontrib><creatorcontrib>Zeng, Zihuan</creatorcontrib><creatorcontrib>Gan, Lidan</creatorcontrib><creatorcontrib>Chen, Jianli</creatorcontrib><creatorcontrib>Han, Hongfei</creatorcontrib><creatorcontrib>Zou, Jianzhong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yanhao</au><au>Wang, Qi</au><au>Luo, Yong</au><au>Jiang, Lu</au><au>Zeng, Zihuan</au><au>Gan, Lidan</au><au>Chen, Jianli</au><au>Han, Hongfei</au><au>Zou, Jianzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Study of Pulsed Versus Continuous High‐Intensity Focused Ultrasound Ablation Using In Vitro and In Vivo Models</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2020-02</date><risdate>2020</risdate><volume>39</volume><issue>2</issue><spage>259</spage><epage>271</epage><pages>259-271</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><abstract>Objectives
To compare the efficacy of pulsed high‐intensity focused ultrasound (PHIFU) versus continuous high‐intensity focused ultrasound (CHIFU) ablation at identical doses.
Methods
Continuous and pulsed HIFU (1200 J) at duty cycles (DCs) of 60% and 20% were examined for their capacity to ablate bovine liver tissue in vitro and rabbit liver tissue in vivo. After ablation, grayscale changes and pathologic characteristics were observed or measured, and the tissue necrosis volume, energy efficiency factor, and average grayscale density were calculated.
Results
The pulsed mode generated greater liquefaction necrosis. An inconspicuous grayscale change was observed for PHIFU at a DC of 20% in some samples, which appeared as an elliptical cavity. The energy efficiency factor of PHIFU at a DC of 60% was significantly lower than that of CHIFU, as observed both in vitro and in vivo (P < .05). The grayscale value and average grayscale density in response to CHIFU were significantly greater than those in response to PHIFU (60% or 20%; P < .05). Histopathologic analysis revealed liquefaction necrosis in all PHIFU groups.
Conclusions
At identical doses, compared with CHIFU, a single session of PHIFU can generate liquefaction necrosis and at a higher DC can improve ablation efficiency. This increased efficacy of PHIFU may involve enhancement of tissue destruction by cavitation effects and a reduction in the obstruction effect of endogenous microbubbles through cavitation effects or a more effective diffusion of heat.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31339599</pmid><doi>10.1002/jum.15098</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2500-0317</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | ablation comparison duty cycle high‐intensity focused ultrasound identical doses |
| title | Comparative Study of Pulsed Versus Continuous High‐Intensity Focused Ultrasound Ablation Using In Vitro and In Vivo Models |
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