Direct effect of the 13-valent pneumococcal conjugate vaccine use on pneumococcal colonization among children in Brazil

Direct effect of the 13-valent pneumococcal conjugate vaccine use on pneumococcal colonization among children in Brazil

•First report in Brazil of the PCV13 direct effect on pneumococcal carriage.•One quarter of the children immunized with PCV13 was colonized.•Colonization with PVC13 serotype was rare.•Multidrug-resistant serotype 6C and non-typeable isolates were found. The 13-valent pneumococcal conjugate vaccine (...

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Veröffentlicht in:Vaccine 2019-08, Vol.37 (36), p.5265-5269
Hauptverfasser: Neves, Felipe P.G., Cardoso, Nayara T., Cardoso, Claudete A.A., Teixeira, Lúcia M., Riley, Lee W.
Format: Artikel
Sprache:eng
Schlagworte:
Age
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial resistance
Ceftriaxone
Children
Children & youth
Colonization
Conjugates
Cough
Disease control
Drug resistance
Erythromycin
Guardians
Immunization
Meningitis
Multidrug resistance
Multidrug resistant organisms
Nasopharyngeal carriage
Pediatrics
Penicillin
Pneumococcal conjugate vaccine
Pneumonia
Population
Serotypes
Streptococcus infections
Streptococcus pneumoniae
Vaccines
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Zusammenfassung:•First report in Brazil of the PCV13 direct effect on pneumococcal carriage.•One quarter of the children immunized with PCV13 was colonized.•Colonization with PVC13 serotype was rare.•Multidrug-resistant serotype 6C and non-typeable isolates were found. The 13-valent pneumococcal conjugate vaccine (PCV13) has been commercially available in Brazil since 2010. We investigated the carriage prevalence, capsular types, and antimicrobial resistance among pneumococci isolated from children immunized with PCV13 in Brazil. We analyzed 500 children 
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.07.056