Immunogenicity of the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) administered concomitantly with the meningococcal serogroup B (4CMenB) vaccine in infants: A post-hoc analysis in a phase 3b, randomised, controlled trial
•PHiD-CV was co-administered with 4CMenB and/or MenC-CRM.•PHiD-CV immunogenicity was assessed in a post-hoc analysis.•Anti-pneumococcal antibody responses did not seem to be impacted by 4CMenB co-administration. No data are currently available on immunogenicity of higher-valent pneumococcal conjugat...
Gespeichert in:
Veröffentlicht in: | Vaccine 2019-08, Vol.37 (35), p.4858-4863 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | •PHiD-CV was co-administered with 4CMenB and/or MenC-CRM.•PHiD-CV immunogenicity was assessed in a post-hoc analysis.•Anti-pneumococcal antibody responses did not seem to be impacted by 4CMenB co-administration.
No data are currently available on immunogenicity of higher-valent pneumococcal conjugate vaccines when co-administered with a 4-component meningococcal serogroup B vaccine (4CMenB).
Post-hoc analysis of pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) immunogenicity when co-administered with 4CMenB (2 + 1 schedule) and/or a CRM-conjugated meningococcal serogroup C vaccine (MenC-CRM) in a trial assessing 4CMenB reduced schedules and co-administration with MenC-CRM (NCT01339923). Infants were randomized to receive 4CMenB and MenC-CRM (Group 1) or MenC-CRM (Group 2) at 3, 5, and 12 months (M) of age. Both groups received PHiD-CV (3 + 1 schedule) as part of the Brazilian national immunisation programme at 3 M, 5 M, 7 M, and 12 M of age. Antibody responses were assessed pre-vaccination, 1 M post-dose 2, pre-booster, and 1 M post-booster.
Anti-pneumococcal antibody responses were in similar ranges in the two study groups.
4CMenB co-administration did not seem to impact antibody responses to PHiD-CV in infants. |
---|---|
ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2019.07.021 |