KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR‐325‐3p

Nonsmall cell lung cancer (NSCLC) is one of the leading causes of cancer‐related death worldwide. Kinesin family member 2C (KIF2C), a modulator in microtubule depolymerization, bipolar spindle formation, and chromosome segregation, has been reported to take roles in cancer biology, but its role in N...

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Veröffentlicht in:	Cell biochemistry and function 2019-08, Vol.37 (6), p.424-431
Hauptverfasser:	Gan, Huizhu, Lin, Lin, Hu, Nanjun, Yang, Yang, Gao, Yu, Pei, Yu, Chen, Kang, Sun, Butong
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis - genetics Carcinogenesis - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell proliferation Chromosome 3 Chromosomes Depolymerization Humans KIF2C Kinesin Kinesin - genetics Kinesin - metabolism Lung cancer Lymph nodes Metastases Metastasis MicroRNAs - genetics MicroRNAs - metabolism miR‐325‐3p Non-small cell lung carcinoma nonsmall cell lung cancer pathology Tumors
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Zusammenfassung:	Nonsmall cell lung cancer (NSCLC) is one of the leading causes of cancer‐related death worldwide. Kinesin family member 2C (KIF2C), a modulator in microtubule depolymerization, bipolar spindle formation, and chromosome segregation, has been reported to take roles in cancer biology, but its role in NSCLC remains unclear. This study was intended to investigate the expression and function of KIF2C in NSCLC. Our results demonstrated that KIF2C was up‐regulated in NSCLC tissues and cell lines. The high expression of KIF2C in NSCLC tissues was significantly correlated with higher T stage (0.0078), worse differentiation status (0.0049), and lymph node metastasis (P
ISSN:	0263-6484 1099-0844
DOI:	10.1002/cbf.3420