Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study

Highlights•Currently used upfront chemotherapy followed by response-adapted RT appears acceptable. •The 5-year OS and EFS rates were 98.8% and 96.6%, respectively. •All basal ganglia germinomas which received local RT relapsed outside the RT field. •Pineal or suprasellar germinomas which received WV...

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Veröffentlicht in:	Radiotherapy and oncology 2019-09, Vol.138, p.180-186
Hauptverfasser:	Lee, Dong Soo, Lim, Do Hoon, Kim, Il Han, Kim, Joo-Young, Han, Jung Woo, Yoo, Keon Hee, Park, Kyung Duk, Park, Hyeon Jin, Chung, Nack-Gyun, Suh, Chang-Ok, Kim, Dong-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Chemotherapy Chemotherapy, Adjuvant Child Child, Preschool Cohort Studies Craniospinal irradiation Disease-Free Survival Female Germinoma Germinoma - drug therapy Germinoma - pathology Germinoma - radiotherapy Hematology, Oncology, and Palliative Medicine Humans Male Neoadjuvant Therapy Neoplasm Recurrence, Local Pineal Gland - pathology Pinealoma - drug therapy Pinealoma - pathology Pinealoma - radiotherapy Prospective Studies Radiotherapy Remission Induction Retrospective Studies Survival Rate Young Adult
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Zusammenfassung:	Highlights•Currently used upfront chemotherapy followed by response-adapted RT appears acceptable. •The 5-year OS and EFS rates were 98.8% and 96.6%, respectively. •All basal ganglia germinomas which received local RT relapsed outside the RT field. •Pineal or suprasellar germinomas which received WVRT did not experience recurrence.
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2019.06.002