Transfusion‐related immune modulation: functional consequence of extracellular vesicles?

Transfusion‐related immune modulation: functional consequence of extracellular vesicles?

KEY IDEAS Extracellular vesicles (EVs) are small, subcellular vesicles that are released from a variety of cells and play important roles in cell‐to‐cell communication. Transfused blood products, including red blood cell, platelet, and plasma products contain EVs that are capable of interacting with...

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Veröffentlicht in:Transfusion (Philadelphia, Pa.) Pa.), 2019-12, Vol.59 (12), p.3553-3555
Hauptverfasser: Menocha, Somaang, Muszynski, Jennifer A.
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Cell interactions
Erythrocytes
Extracellular vesicles
Immune system
Immunomodulation
Transfusion
Vesicles
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Zusammenfassung:KEY IDEAS Extracellular vesicles (EVs) are small, subcellular vesicles that are released from a variety of cells and play important roles in cell‐to‐cell communication. Transfused blood products, including red blood cell, platelet, and plasma products contain EVs that are capable of interacting with and altering immune cell function. The extent to which EVs may contribute to clinically meaningful immunomodulatory effects of transfusion remains unclear and deserving of further study.
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.15461