Challenging (immunogenically) silent assumptions

Zamora et al. challenge the assumption that paediatric acute lymphoblastic leukaemia (ALL), a low mutational burden cancer, is immunogenically silent. The authors report that paediatric ALLs are, in fact, antigenically visible and elicit robust, albeit ineffective, antitumour CD8 + T cell responses.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Cancer 2019-09, Vol.19 (9), p.483-483
1. Verfasser:	Bradley, Conor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283/2125 631/67/2332 631/67/580 Acute lymphocytic leukemia Biomedical and Life Sciences Biomedicine Biopsy Cancer Research Care and treatment CD8-Positive T-Lymphocytes Child Gene expression Genetic aspects Humans Pediatric research Precursor Cell Lymphoblastic Leukemia-Lymphoma Research Highlight T cells
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Beschreibung
Zusammenfassung:	Zamora et al. challenge the assumption that paediatric acute lymphoblastic leukaemia (ALL), a low mutational burden cancer, is immunogenically silent. The authors report that paediatric ALLs are, in fact, antigenically visible and elicit robust, albeit ineffective, antitumour CD8 + T cell responses.
ISSN:	1474-175X 1474-1768
DOI:	10.1038/s41568-019-0181-1