1,3‐Difunctionalization of Aminocyclopropanes via Dielectrophilic Intermediates

We report an oxidative ring‐opening strategy to transform acyl, sulfonyl or carbamate protected aminocyclopropanes into 1,3‐dielectrophilic carbon intermediates bearing a halide atom (Br, I) and a N,O‐acetal. Replacing the alkoxy group of the N,O‐acetal can be achieved under acidic conditions through an elimination–addition pathway, while substitution of the halides by nucleophiles can be done under basic conditions through a SN2 pathway, generating a wide range of 1,3‐difunctionalized propylamines. A proof of concept for asymmetric induction was realized using a chiral phosphoric acid (CPA) as catalyst, highlighting the potential of the method in enantioselective synthesis of important building blocks. Choose your nucleophiles: We report an oxidative ring‐opening strategy to transform aminocyclopropanes into 1,3‐dielectrophilic halogenated N,O‐acetals. Substitution of either the alkoxy group of the N,O‐acetal or the halide by a series of nucleophiles then generates a broad range of 1,3‐difunctionalized propylamines.