Early Blood Pressure Reduction by Intravenous Vasodilators Is Associated With Acute Kidney Injury in Patients With Hypertensive Acute Decompensated Heart

Background:Intravenous vasodilators are commonly used in patients with hypertensive acute decompensated heart failure (ADHF), but little is known about their optimal use in blood pressure (BP) management to avoid acute kidney injury (AKI). The purpose of this study was to investigate the association...

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Veröffentlicht in:Circulation Journal 2019/08/23, Vol.83(9), pp.1883-1890
Hauptverfasser: Arao, Yoshihito, Sawamura, Akinori, Nakatochi, Masahiro, Okumura, Takahiro, Kato, Hiroo, Oishi, Hideo, Yamaguchi, Shogo, Haga, Tomoaki, Kuwayama, Tasuku, Yokoi, Tsuyoshi, Hiraiwa, Hiroaki, Kondo, Toru, Morimoto, Ryota, Murohara, Toyoaki
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Sprache:eng
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Zusammenfassung:Background:Intravenous vasodilators are commonly used in patients with hypertensive acute decompensated heart failure (ADHF), but little is known about their optimal use in blood pressure (BP) management to avoid acute kidney injury (AKI). The purpose of this study was to investigate the association between systolic BP (SBP) changes and the incidence of AKI in patients with hypertensive ADHF.Methods and Results:Post-hoc analysis was performed on a prospectively enrolled cohort. We investigated 245 patients with ADHF and SBP >140 mmHg on arrival (mean age, 76 years; 40% female). We defined “SBP-fall” as the maximum percent reduction in SBP 6 h after intravenous treatment. AKI was defined as serum creatinine (SCr) ≥0.3 mg/dL, or urine output
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-19-0333