Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries
Background Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes. Purpose We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development. Methods...
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| Veröffentlicht in: | Obesity surgery 2019-12, Vol.29 (12), p.3901-3906 |
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| creator | Dicker, Dror Comaneshter, Doron S. Yahalom, Rina Cohen, Chagit Adler Vinker, Shlomo Golan, Rachel |
| description | Background
Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes.
Purpose
We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development.
Methods
We accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100–125 mg/dL (5.6–6.9 mmol/L) or HbA1c 5.7–6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002–2011.
Results
Of 1,756 individuals with prediabetes, 819 underwent gastric banding (GB), 845 sleeve gastrectomy (SG), and 92 Roux-en-Y gastric bypass (RYGB). Mean age was 41.6 years and 73.5% were women. Five years post-surgery, 177 (10.1%) had developed diabetes. Conversion rates by type of surgery were 14.4%, 6.3%, and 6.5% for GB, SG, and RYGB, respectively (
p
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| doi_str_mv | 10.1007/s11695-019-04090-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2259354809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2258488050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-2fcca6f41e0052a7793fa7fb453890770911dded06b14bcb6b39a1df7c1086693</originalsourceid><addsrcrecordid>eNp9kU1vEzEQhi0EoqHwBzggS1w4xDC298M-0gClUqVWKhw4Wd71LLhK1sGzGxSJH49DWpA4IB_skZ95x_LD2HMJryVA-4akbGwtQFoBFVgQ8gFbyBZMKZV5yBZgGxDGKn3CnhDdAijZKPWYnWhZltJ2wX6u0rjDTDGNfMhpw68zhug7nJD4lPi7-3Mc-cUY4i6G2a-J_4jTN37VIcVpv-S1-II-E79ONIkzP4Ylv1kj7nDJS8HPPU059vxsv_VE_GbOXzFHpKfs0VDC8Nndfso-f3j_afVRXF6dX6zeXopet_Uk1ND3vhkqiQC18m1r9eDboatqbSy0LVgpQ8AATSerru-aTlsvw9D2EkzTWH3KXh1ztzl9n5Emt4nU43rtR0wzOaVqq-vKwAF9-Q96m-Y8ltcdKFMZAzUUSh2pPieijIPb5rjxee8kuIMbd3Tjihv3242TpenFXfTcbTD8abmXUQB9BKhcjeWL_s7-T-wv1A-ZIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2258488050</pqid></control><display><type>article</type><title>Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Dicker, Dror ; Comaneshter, Doron S. ; Yahalom, Rina ; Cohen, Chagit Adler ; Vinker, Shlomo ; Golan, Rachel</creator><creatorcontrib>Dicker, Dror ; Comaneshter, Doron S. ; Yahalom, Rina ; Cohen, Chagit Adler ; Vinker, Shlomo ; Golan, Rachel</creatorcontrib><description>Background
Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes.
Purpose
We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development.
Methods
We accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100–125 mg/dL (5.6–6.9 mmol/L) or HbA1c 5.7–6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002–2011.
Results
Of 1,756 individuals with prediabetes, 819 underwent gastric banding (GB), 845 sleeve gastrectomy (SG), and 92 Roux-en-Y gastric bypass (RYGB). Mean age was 41.6 years and 73.5% were women. Five years post-surgery, 177 (10.1%) had developed diabetes. Conversion rates by type of surgery were 14.4%, 6.3%, and 6.5% for GB, SG, and RYGB, respectively (
p
< 0.001). Conversion was more rapid following GB than SG or RYGB (
χ
2
(2) = 29.67,
p
< 0.005). In a multiple-logistic-regression model, predictors of diabetes development 5 years postoperatively were (1) weight loss during the first postoperative year and (2) preoperative levels of both FG and HbA1c within the prediabetes range. Baseline weight, age, and sex, were not associated with conversion to diabetes. Conversion rates were lower (4.7%) five years postoperatively for patients who lost > 25% of their baseline weight, compared to those who lost less than 15% of their weight during the first postoperative year: (14.0% < 0.001).
Conclusions
Our findings emphasize the importance of preoperative glycemic control and weight loss during the first year postoperatively, for the long-term prevention of diabetes in patients with prediabetes undergoing metabolic surgery.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-019-04090-1</identifier><identifier>PMID: 31313239</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Bariatric Surgery - methods ; Biomarkers - blood ; Blood Glucose - metabolism ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Female ; Follow-Up Studies ; Gastrointestinal surgery ; Humans ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - complications ; Obesity, Morbid - physiopathology ; Obesity, Morbid - surgery ; Original Contributions ; Postoperative Complications - blood ; Postoperative Complications - diagnosis ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Prediabetic State - etiology ; Prediabetic State - physiopathology ; Risk Factors ; Surgery ; Weight control ; Weight Loss</subject><ispartof>Obesity surgery, 2019-12, Vol.29 (12), p.3901-3906</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Obesity Surgery is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-2fcca6f41e0052a7793fa7fb453890770911dded06b14bcb6b39a1df7c1086693</citedby><cites>FETCH-LOGICAL-c375t-2fcca6f41e0052a7793fa7fb453890770911dded06b14bcb6b39a1df7c1086693</cites><orcidid>0000-0001-8546-6245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-019-04090-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-019-04090-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31313239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dicker, Dror</creatorcontrib><creatorcontrib>Comaneshter, Doron S.</creatorcontrib><creatorcontrib>Yahalom, Rina</creatorcontrib><creatorcontrib>Cohen, Chagit Adler</creatorcontrib><creatorcontrib>Vinker, Shlomo</creatorcontrib><creatorcontrib>Golan, Rachel</creatorcontrib><title>Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes.
Purpose
We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development.
Methods
We accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100–125 mg/dL (5.6–6.9 mmol/L) or HbA1c 5.7–6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002–2011.
Results
Of 1,756 individuals with prediabetes, 819 underwent gastric banding (GB), 845 sleeve gastrectomy (SG), and 92 Roux-en-Y gastric bypass (RYGB). Mean age was 41.6 years and 73.5% were women. Five years post-surgery, 177 (10.1%) had developed diabetes. Conversion rates by type of surgery were 14.4%, 6.3%, and 6.5% for GB, SG, and RYGB, respectively (
p
< 0.001). Conversion was more rapid following GB than SG or RYGB (
χ
2
(2) = 29.67,
p
< 0.005). In a multiple-logistic-regression model, predictors of diabetes development 5 years postoperatively were (1) weight loss during the first postoperative year and (2) preoperative levels of both FG and HbA1c within the prediabetes range. Baseline weight, age, and sex, were not associated with conversion to diabetes. Conversion rates were lower (4.7%) five years postoperatively for patients who lost > 25% of their baseline weight, compared to those who lost less than 15% of their weight during the first postoperative year: (14.0% < 0.001).
Conclusions
Our findings emphasize the importance of preoperative glycemic control and weight loss during the first year postoperatively, for the long-term prevention of diabetes in patients with prediabetes undergoing metabolic surgery.</description><subject>Adult</subject><subject>Bariatric Surgery - methods</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Prediabetic State - etiology</subject><subject>Prediabetic State - physiopathology</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1vEzEQhi0EoqHwBzggS1w4xDC298M-0gClUqVWKhw4Wd71LLhK1sGzGxSJH49DWpA4IB_skZ95x_LD2HMJryVA-4akbGwtQFoBFVgQ8gFbyBZMKZV5yBZgGxDGKn3CnhDdAijZKPWYnWhZltJ2wX6u0rjDTDGNfMhpw68zhug7nJD4lPi7-3Mc-cUY4i6G2a-J_4jTN37VIcVpv-S1-II-E79ONIkzP4Ylv1kj7nDJS8HPPU059vxsv_VE_GbOXzFHpKfs0VDC8Nndfso-f3j_afVRXF6dX6zeXopet_Uk1ND3vhkqiQC18m1r9eDboatqbSy0LVgpQ8AATSerru-aTlsvw9D2EkzTWH3KXh1ztzl9n5Emt4nU43rtR0wzOaVqq-vKwAF9-Q96m-Y8ltcdKFMZAzUUSh2pPieijIPb5rjxee8kuIMbd3Tjihv3242TpenFXfTcbTD8abmXUQB9BKhcjeWL_s7-T-wv1A-ZIg</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Dicker, Dror</creator><creator>Comaneshter, Doron S.</creator><creator>Yahalom, Rina</creator><creator>Cohen, Chagit Adler</creator><creator>Vinker, Shlomo</creator><creator>Golan, Rachel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8546-6245</orcidid></search><sort><creationdate>20191201</creationdate><title>Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries</title><author>Dicker, Dror ; Comaneshter, Doron S. ; Yahalom, Rina ; Cohen, Chagit Adler ; Vinker, Shlomo ; Golan, Rachel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-2fcca6f41e0052a7793fa7fb453890770911dded06b14bcb6b39a1df7c1086693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Bariatric Surgery - methods</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Prediabetic State - etiology</topic><topic>Prediabetic State - physiopathology</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dicker, Dror</creatorcontrib><creatorcontrib>Comaneshter, Doron S.</creatorcontrib><creatorcontrib>Yahalom, Rina</creatorcontrib><creatorcontrib>Cohen, Chagit Adler</creatorcontrib><creatorcontrib>Vinker, Shlomo</creatorcontrib><creatorcontrib>Golan, Rachel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dicker, Dror</au><au>Comaneshter, Doron S.</au><au>Yahalom, Rina</au><au>Cohen, Chagit Adler</au><au>Vinker, Shlomo</au><au>Golan, Rachel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>29</volume><issue>12</issue><spage>3901</spage><epage>3906</epage><pages>3901-3906</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes.
Purpose
We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development.
Methods
We accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100–125 mg/dL (5.6–6.9 mmol/L) or HbA1c 5.7–6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002–2011.
Results
Of 1,756 individuals with prediabetes, 819 underwent gastric banding (GB), 845 sleeve gastrectomy (SG), and 92 Roux-en-Y gastric bypass (RYGB). Mean age was 41.6 years and 73.5% were women. Five years post-surgery, 177 (10.1%) had developed diabetes. Conversion rates by type of surgery were 14.4%, 6.3%, and 6.5% for GB, SG, and RYGB, respectively (
p
< 0.001). Conversion was more rapid following GB than SG or RYGB (
χ
2
(2) = 29.67,
p
< 0.005). In a multiple-logistic-regression model, predictors of diabetes development 5 years postoperatively were (1) weight loss during the first postoperative year and (2) preoperative levels of both FG and HbA1c within the prediabetes range. Baseline weight, age, and sex, were not associated with conversion to diabetes. Conversion rates were lower (4.7%) five years postoperatively for patients who lost > 25% of their baseline weight, compared to those who lost less than 15% of their weight during the first postoperative year: (14.0% < 0.001).
Conclusions
Our findings emphasize the importance of preoperative glycemic control and weight loss during the first year postoperatively, for the long-term prevention of diabetes in patients with prediabetes undergoing metabolic surgery.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31313239</pmid><doi>10.1007/s11695-019-04090-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8546-6245</orcidid></addata></record> |
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| subjects | Adult Bariatric Surgery - methods Biomarkers - blood Blood Glucose - metabolism Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Female Follow-Up Studies Gastrointestinal surgery Humans Logistic Models Male Medicine Medicine & Public Health Metabolism Middle Aged Obesity Obesity, Morbid - complications Obesity, Morbid - physiopathology Obesity, Morbid - surgery Original Contributions Postoperative Complications - blood Postoperative Complications - diagnosis Postoperative Complications - epidemiology Postoperative Complications - etiology Prediabetic State - etiology Prediabetic State - physiopathology Risk Factors Surgery Weight control Weight Loss |
| title | Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries |
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