Investigating subtle kidney injury in primary hyperparathyroidism by means of sensitive and specific biomarkers

Investigating subtle kidney injury in primary hyperparathyroidism by means of sensitive and specific biomarkers

Objective Kidney involvement is a common complication in primary hyperparathyroidism (PHPT). No study so far has assessed the prevalence of kidney injury developing before the reduction in glomerular filtration rate (GFR) in PHPT. The study was aimed at establishing the potential role of biomarkers...

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Veröffentlicht in:Clinical endocrinology (Oxford) 2019-11, Vol.91 (5), p.660-668
Hauptverfasser: Cipriani, Cristiana, Pepe, Jessica, Colangelo, Luciano, Fassino, Valeria, Occhiuto, Marco, Biondi, Piergianni, Nieddu, Luciano, Minisola, Salvatore
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Calculi
Chronic infection
chronic kidney disease
Contrast media
Fibroblast growth factor 23
Glomerular filtration rate
Heart diseases
Hyperparathyroidism
Inflammatory diseases
injury
kidney
Kidneys
Klotho protein
Malignancy
Nephrolithiasis
Nephrotic syndrome
Parathyroid hormone
Post-menopause
primary hyperparathyroidism
Urine
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Zusammenfassung:Objective Kidney involvement is a common complication in primary hyperparathyroidism (PHPT). No study so far has assessed the prevalence of kidney injury developing before the reduction in glomerular filtration rate (GFR) in PHPT. The study was aimed at establishing the potential role of biomarkers of kidney injury in detecting subtle renal damage in patients with PHPT. Design Cross‐sectional study. Patients A total of 69 postmenopausal patients with PHPT and 41 healthy age‐ and sex‐matched subjects were studied. Exclusion criteria were as follows: GFR 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14064