Global DNA Methylation Pattern of Fibroblasts in Idiopathic Pulmonary Fibrosis

Global DNA Methylation Pattern of Fibroblasts in Idiopathic Pulmonary Fibrosis

Our previous transcriptome study of cultured fibroblasts identified 178 genes that were differentially expressed by 8 idiopathic pulmonary fibrosis (IPF) fibroblasts compared with 4 controls. Here, we performed genome-wide DNA methylation analysis to evaluate the relationship of CpG methylation to d...

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Veröffentlicht in:DNA and cell biology 2019-09, Vol.38 (9), p.905-914
Hauptverfasser: Lee, Jong-Uk, Son, Ji-Hye, Shim, Eun-Young, Cheong, Hyun Sub, Shin, Seung-Woo, Shin, Hyoung Doo, Baek, Ae Rin, Ryu, Seongho, Park, Choon-Sik, Chang, Hun Soo, Park, Jong-Sook
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Cell adhesion
Cell adhesion & migration
Cell adhesion molecules
CpG islands
Deoxyribonucleic acid
DNA
DNA methylation
Fibroblasts
Fibrosis
Gene expression
Genes
Genomes
Homeostasis
Loci
Lung diseases
Lungs
Organic chemistry
Pathogenesis
Pulmonary fibrosis
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Zusammenfassung:Our previous transcriptome study of cultured fibroblasts identified 178 genes that were differentially expressed by 8 idiopathic pulmonary fibrosis (IPF) fibroblasts compared with 4 controls. Here, we performed genome-wide DNA methylation analysis to evaluate the relationship of CpG methylation to differential gene expression. Among 485,577 loci, 5850 loci on 2282 genes showed significant differences between the 2 groups (delta-beta >10.21 and -value
ISSN:1044-5498
1557-7430
DOI:10.1089/dna.2018.4557