Differences in clinico-pathological characteristics and outcomes between proteinase 3-ANCA positivity and myeloperoxidase-ANCA positivity in lupus nephritis

Background Owing to the low prevalence of anti-neutrophil cytoplasmic antibodies (ANCA) in lupus nephritis (LN), there is no study about the differences between proteinase 3 (PR3)-ANCA positivity and myeloperoxidase (MPO)-ANCA positivity in LN until now. Methods Here we perform a retrospective study...

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Veröffentlicht in:	Lupus 2019-08, Vol.28 (9), p.1111-1119
Hauptverfasser:	Li, C, Wang, J -J, Zhou, M -L, Liang, D -D, Yang, J, Zhu, H -X, Hu, W -X, Zhang, H -T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Antineutrophil Cytoplasmic - immunology Antibodies, Antinuclear - immunology Antineutrophil cytoplasmic antibodies Antinuclear antibodies Atrophy Biopsy Cohort Studies Creatinine Creatinine - blood Female Fibrosis Follow-Up Studies Humans Lupus Lupus nephritis Lupus Nephritis - immunology Lupus Nephritis - physiopathology Male Myeloblastin - immunology Nephritis Peroxidase Peroxidase - immunology Proteinase Proteinase 3 Renal function Retrospective Studies Serology Young Adult
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Zusammenfassung:	Background Owing to the low prevalence of anti-neutrophil cytoplasmic antibodies (ANCA) in lupus nephritis (LN), there is no study about the differences between proteinase 3 (PR3)-ANCA positivity and myeloperoxidase (MPO)-ANCA positivity in LN until now. Methods Here we perform a retrospective study to determine whether there are differences in clinic-pathological characteristics and renal outcomes between PR3-ANCA-positive LN patients and MPO-ANCA-positive LN patients. Results A total of 26 (27.4%) PR3-ANCA-positive LN patients and 69 (72.6%) MPO-ANCA-positive LN patients (p
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203319861680