TERT assists GDF11 to rejuvenate senescent VEGFR2+/CD133+ cells in elderly patients with myocardial infarction

Growth differentiation factor 11 (GDF11) is a transforming growth factor β superfamily member with a controversial role in rejuvenating old stem cells after acute injury in the elderly population. This study aimed to evaluate the effects of telomerase reverse transcriptase (TERT) on GDF11-mediated r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Laboratory investigation 2019-11, Vol.99 (11), p.1661-1688
Hauptverfasser:	Zhao, Lan, Zhang, Shaoheng, Cui, Jin, Huang, Weiguang, Wang, Jiahong, Su, Feng, Chen, Nannan, Gong, Qunlin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/2 13/21 13/31 14/19 38/109 45/29 631/1647/1407/651 631/80/82/23 631/80/86/2368 692/699/75/2/1674 692/699/75/593/15/1939 96/95 AC133 Antigen - metabolism Adult Adult Stem Cells - metabolism Adult Stem Cells - pathology Aged Aged, 80 and over Aging - blood Aging - metabolism Aging - pathology Angiocardiography Angiogenesis Animals Bone Morphogenetic Proteins - metabolism Cellular Senescence Depletion Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Female Geriatrics Growth differentiation factor 11 Growth Differentiation Factors - metabolism Growth factors Heart attacks Humans Laboratory Medicine Leukocyte Count Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - pathology Male Medicine Medicine & Public Health Middle Aged Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - metabolism Myocardial Infarction - pathology Neovascularization, Physiologic Nitric Oxide Synthase Type III - metabolism Older people Pathology Population studies Progenitor cells Rats Rats, Sprague-Dawley RNA-directed DNA polymerase Senescence Signal Transduction Smad2 protein Stem cells Survival Telomerase Telomerase - metabolism Telomerase reverse transcriptase Therapeutic applications Transforming growth factor-b Vascular Endothelial Growth Factor Receptor-2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Growth differentiation factor 11 (GDF11) is a transforming growth factor β superfamily member with a controversial role in rejuvenating old stem cells after acute injury in the elderly population. This study aimed to evaluate the effects of telomerase reverse transcriptase (TERT) on GDF11-mediated rejuvenation of senescent late-outgrowth endothelial progenitor cells (EPCs), defined as VEGFR2+/CD133+ cells, in elderly patients with acute myocardial infarction (AMI). We compared the quantity and capabilities of VEGFR2+/CD133+ cells from old (>60 years), middle-aged (45–60 years), and young (
ISSN:	0023-6837 1530-0307
DOI:	10.1038/s41374-019-0290-1