Association of Gene Polymorphisms in the Human MicroRNA-126 Gene with Plasma-Circulating MicroRNA-126 Levels and Acute Myocardial Infarction

Our objective was to study the association of the human microRNA-126 ( ) gene rs4636297 and rs1140713 polymorphisms and the plasma-circulating level in acute myocardial infarction (AMI). The genotypes of the gene rs4636297 and rs1140713 loci were characterized by the direct sequencing method in 350...

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Veröffentlicht in:	Genetic testing and molecular biomarkers 2019-07, Vol.23 (7), p.460-467
Hauptverfasser:	Hu, Haiqiang, Yuan, Hong, Li, Cairong, Yu, Huamin, Chen, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Brain Brain natriuretic peptide Calcium-binding protein Cholesterol Cholesterol, LDL - blood Circulating MicroRNA - genetics Confidence intervals Female Gene expression Gene sequencing Genetic Association Studies Genotype Genotypes Growth factors Health risk assessment Heart attacks Humans Levels Loci Low density lipoprotein Male MicroRNAs MicroRNAs - blood MicroRNAs - genetics Middle Aged miRNA Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - genetics Natriuretic Peptide, Brain - blood Nucleotides Polymerase chain reaction Polymorphism, Single Nucleotide Real-Time Polymerase Chain Reaction Reverse transcription Ribonucleic acid RNA Single-nucleotide polymorphism Troponin Troponin I Troponin I - blood Vascular endothelial growth factor
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Zusammenfassung:	Our objective was to study the association of the human microRNA-126 ( ) gene rs4636297 and rs1140713 polymorphisms and the plasma-circulating level in acute myocardial infarction (AMI). The genotypes of the gene rs4636297 and rs1140713 loci were characterized by the direct sequencing method in 350 AMI patients and 350 healthy controls. The level of plasma-circulating was measured by reverse transcription real-time polymerase chain reaction. Plasma-free levels and Gensini scores ( = -0.684,
ISSN:	1945-0265 1945-0257
DOI:	10.1089/gtmb.2018.0282