Hijack of CRISPR defences by selfish genes holds clinical promise

Hijack of CRISPR defences by selfish genes holds clinical promise

Parasitic genetic elements called transposons carry CRISPR machinery that is normally used against them by bacterial cells. This paradox has now been explained, with implications for gene-therapy research. RNA-guided transposition of DNA.

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2019-07, Vol.571 (7764), p.180-181
1. Verfasser: Urnov, Fyodor D.
Format: Artikel
Sprache:eng
Schlagworte:
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Analysis
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Cas Systems
DNA
Evolutionary genetics
Gene Editing
Genetic research
Molecular machines
News And Views
RNA
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Beschreibung
Zusammenfassung:Parasitic genetic elements called transposons carry CRISPR machinery that is normally used against them by bacterial cells. This paradox has now been explained, with implications for gene-therapy research. RNA-guided transposition of DNA.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-019-01824-0