Management of solid pseudopapillary neoplasms of pancreas: A single center experience of 243 consecutive patients

Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare neoplasm, which mainly affects young women. The aim of this study was to investigate the clinicopathological features and surgical management of SPNs in our institution. Patients who underwent surgery for a pathologically confirmed SPN in our institution between January 2008 and October 2018 were collected. Their clinical characteristics and survival associations were analyzed. In total, 243 pathologically confirmed patients were analyzed in this study, including 181(74.5%)females and 62(25.5%) males. The mean age was 35.3 years old (range: 12–64 years old) with average tumor size of 4.83 cm (range: 0.8–16 cm). 239 patients underwent complete surgical resection. After median follow-up of 46 months (range: 10–118 months), four patients died due to tumor progression. All the other people were absent of local recurrence or distant metastasis. SPN is a latent malignant tumor with excellent prognosis. Surgical resection is recommended even in the presence of liver metastasis. If possible, function-preserving surgery is advocated. High Ki67 index may predict the malignant potential and poor prognosis of SPNs.