Bursting Enables GRP Neurons to Engage Spinal Itch Circuits

In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain. In this issue of Neuron, Pagani et al. (2019) find that it...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2019-07, Vol.103 (1), p.5-7
Hauptverfasser:	Petitjean, Hugues, Séguéla, Philippe, Sharif-Naeini, Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Communication Neurons Neuropeptides Pain Peptides Spinal cord
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description	In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain. In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain.
doi_str_mv	10.1016/j.neuron.2019.06.009
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subjects	Communication Neurons Neuropeptides Pain Peptides Spinal cord
title	Bursting Enables GRP Neurons to Engage Spinal Itch Circuits
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