Bursting Enables GRP Neurons to Engage Spinal Itch Circuits

Bursting Enables GRP Neurons to Engage Spinal Itch Circuits

In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain. In this issue of Neuron, Pagani et al. (2019) find that it...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2019-07, Vol.103 (1), p.5-7
Hauptverfasser: Petitjean, Hugues, Séguéla, Philippe, Sharif-Naeini, Reza
Format: Artikel
Sprache:eng
Schlagworte:
Communication
Neurons
Neuropeptides
Pain
Peptides
Spinal cord
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Zusammenfassung:In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain. In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2019.06.009