Highly efficient electrochemical recognition and quantification of amine enantiomers based on a guest-free homochiral MOF

We facilely synthesized a novel guest-free homochiral metal–organic framework, (Cu 4 L 4 ) n [H 2 L = N -(2-hydroxybenzyl)- l -leucine] in space group P 1. The (Cu 4 L 4 ) n nanocrystals exhibit high electrochemical activity for rapidly discriminating chiral α-methylbenzylamine enantiomers and quantitatively determining the enantiomeric excess in the chiral amine mixture.