Perioperative stroke associated in-hospital morbidity and in-hospital mortality in common non-vascular non-neurological surgery

•Perioperative stroke is a relatively infrequent event; however, it can result in a debilitating deficit.•Our study found in-hospital morbidity, mortality, and perioperative stroke rate of 5.5%, 0.8%, and 0.2%, respectively.•Perioperative stroke impact on in-hospital mortality was (odds ratio = 8.53, 95% confidence intervals: 7.87–9.25).•Perioperative stroke was an independent risk factor for in-hospital morbidity.•Intraoperative neuromonitoring (IONM) and interventional thrombectomy uses should be further studied and developed. Perioperative stroke in non-vascular, non-neurological surgery is a potential cause of high levels of in-hospital morbidity and mortality. Although, perioperative stroke following non-vascular and non-neurological surgery is a relatively infrequent event; high surgical volume results in thousands of patients experiencing neurological deficits. We aim to determine if perioperative stroke is an independent risk factor for 30-day in-hospital morbidity and mortality following common non-vascular non-neurological surgery. This is a retrospective analysis of 4,264,963 surgical procedures identified in the Nationwide Inpatient Sample (NIS) from the years 2000 through 2011. The exposure of interest was stroke within 30 days of total knee arthroscopy, total hip arthroscopy, lung segmentation and resection, appendectomy, hemicolectomy, cholecystectomy, and lysis of peritoneal adhesions. Study outcomes were in-hospital mortality and in-hospital morbidity. Our study found an in-hospital morbidity, in-hospital mortality, and perioperative stroke rate of 5.5%, 0.8%, and 0.2%, respectively. Multivariable analysis revealed perioperative stroke to be a significant independent predictor (p