Insufficient slow-flow suppression mimicking aneurysm wall enhancement in magnetic resonance vessel wall imaging: a phantom study

MR vessel wall imaging (VWI) is increasingly performed in clinical settings to support treatment decision-making regarding intracranial aneurysms. Aneurysm wall enhancement after contrast agent injection is expected to be related to aneurysm instability and rupture status. However, the authors hypot...

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Veröffentlicht in:Neurosurgical focus 2019-07, Vol.47 (1), p.E19-E19
Hauptverfasser: Cornelissen, Bart M W, Leemans, Eva L, Coolen, Bram F, Peper, Eva S, van den Berg, René, Marquering, Henk A, Slump, Cornelis H, Majoie, Charles B L M
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container_issue 1
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container_title Neurosurgical focus
container_volume 47
creator Cornelissen, Bart M W
Leemans, Eva L
Coolen, Bram F
Peper, Eva S
van den Berg, René
Marquering, Henk A
Slump, Cornelis H
Majoie, Charles B L M
description MR vessel wall imaging (VWI) is increasingly performed in clinical settings to support treatment decision-making regarding intracranial aneurysms. Aneurysm wall enhancement after contrast agent injection is expected to be related to aneurysm instability and rupture status. However, the authors hypothesize that slow-flow artifacts mimic aneurysm wall enhancement. Therefore, in this phantom study they assess the effect of slow flow on wall-like enhancement by using different MR VWI techniques. The authors developed an MR-compatible aneurysm phantom model, which was connected to a pump to enable pulsatile inflow conditions. For VWI, 3D turbo spin echo sequences-both with and without motion-sensitized driven equilibrium (MSDE) and delay alternating with nutation for tailored excitation (DANTE) preparation pulses-were performed using a 3-T MR scanner. VWI was acquired both before and after Gd contrast agent administration by using two different pulsatile inflow conditions (2.5 ml/sec peak flow at 77 and 48 beats per minute). The intraluminal signal intensity along the aneurysm wall was analyzed to assess the performance of slow-flow suppression. The authors observed wall-like enhancement after contrast agent injection, especially in low pump rate settings. Preparation pulses, in particular the DANTE technique, improved the performance of slow-flow suppression. Near-wall slow flow mimics wall enhancement in VWI protocols. Therefore, VWI should be carefully interpreted. Preparation pulses improve slow-flow suppression, and therefore the authors encourage further development and clinical implementation of these techniques.
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The intraluminal signal intensity along the aneurysm wall was analyzed to assess the performance of slow-flow suppression. The authors observed wall-like enhancement after contrast agent injection, especially in low pump rate settings. Preparation pulses, in particular the DANTE technique, improved the performance of slow-flow suppression. Near-wall slow flow mimics wall enhancement in VWI protocols. Therefore, VWI should be carefully interpreted. 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The intraluminal signal intensity along the aneurysm wall was analyzed to assess the performance of slow-flow suppression. The authors observed wall-like enhancement after contrast agent injection, especially in low pump rate settings. Preparation pulses, in particular the DANTE technique, improved the performance of slow-flow suppression. Near-wall slow flow mimics wall enhancement in VWI protocols. Therefore, VWI should be carefully interpreted. Preparation pulses improve slow-flow suppression, and therefore the authors encourage further development and clinical implementation of these techniques.</abstract><cop>United States</cop><pmid>31261123</pmid><doi>10.3171/2019.4.focus19235</doi><oa>free_for_read</oa></addata></record>
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title Insufficient slow-flow suppression mimicking aneurysm wall enhancement in magnetic resonance vessel wall imaging: a phantom study
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