T cells CD4+/CD8+ local immune modulation by prostate cancer hemi-cryoablation

Purpose Tumors escape from the immune system by decreasing CD8+ and increasing CD4+ T cells’ activity, druggable targets. Thermal ablation might activate tumor-specific T cells by raising the presentation of tumor-specific antigens and hindering tumor negative immune regulation. Our aim was to asses...

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Veröffentlicht in:	World journal of urology 2020-03, Vol.38 (3), p.673-680
Hauptverfasser:	Cerqueira, Michael A., Ferrari, Karen L., de Mattos, Amilcar C., Monti, Carlos R., Reis, Leonardo Oliveira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - pathology Adenocarcinoma - surgery Antigen (tumor-associated) Antigen presentation Biopsy CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cryosurgery - methods Diagnosis Humans Immune system Immunohistochemistry Immunomodulation Immunoregulation Life Sciences & Biomedicine Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Male Medicine Medicine & Public Health Neoplasm Staging Nephrology Oncology Original Article Prospective Studies Prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Science & Technology Tumor Microenvironment - immunology Urology Urology & Nephrology
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Zusammenfassung:	Purpose Tumors escape from the immune system by decreasing CD8+ and increasing CD4+ T cells’ activity, druggable targets. Thermal ablation might activate tumor-specific T cells by raising the presentation of tumor-specific antigens and hindering tumor negative immune regulation. Our aim was to assess T cell infiltrate pre- and post-cryoablation in a prospective observational study. Methods A total of 240 sextant prostate biopsies cores (12 cores/patient) were collected from 10 unilateral prostate cancer patients (T1c, PSA density
ISSN:	0724-4983 1433-8726
DOI:	10.1007/s00345-019-02861-0