Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

In cases of suspected meningitis or encephalitis that were difficult to diagnose, metagenomic sequencing of CSF was used to attempt to determine the etiologic agent. Metagenomic sequencing was able to determine a likely pathologic agent that was clinically actionable in some cases.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2019-06, Vol.380 (24), p.2327-2340
Hauptverfasser:	Wilson, Michael R, Sample, Hannah A, Zorn, Kelsey C, Arevalo, Shaun, Yu, Guixia, Neuhaus, John, Federman, Scot, Stryke, Doug, Briggs, Benjamin, Langelier, Charles, Berger, Amy, Douglas, Vanja, Josephson, S. Andrew, Chow, Felicia C, Fulton, Brent D, DeRisi, Joseph L, Gelfand, Jeffrey M, Naccache, Samia N, Bender, Jeffrey, Dien Bard, Jennifer, Murkey, Jamie, Carlson, Magrit, Vespa, Paul M, Vijayan, Tara, Allyn, Paul R, Campeau, Shelley, Humphries, Romney M, Klausner, Jeffrey D, Ganzon, Czarina D, Memar, Fatemeh, Ocampo, Nicolle A, Zimmermann, Lara L, Cohen, Stuart H, Polage, Christopher R, DeBiasi, Roberta L, Haller, Barbara, Dallas, Ronald, Maron, Gabriela, Hayden, Randall, Messacar, Kevin, Dominguez, Samuel R, Miller, Steve, Chiu, Charles Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Cerebrospinal fluid Cerebrospinal Fluid - microbiology Cerebrospinal Fluid - virology Child Child, Preschool Diagnosis Diagnostic tests Encephalitis Encephalitis - diagnosis Encephalitis - microbiology Female Genome, Microbial High-Throughput Nucleotide Sequencing Humans Infant Infections Infections - diagnosis Invasiveness Length of Stay Male Medical diagnosis Medical laboratories Meningitis Meningitis - diagnosis Meningitis - microbiology Meningoencephalitis - diagnosis Meningoencephalitis - microbiology Metagenomics Middle Aged Myelitis - diagnosis Myelitis - microbiology Nervous system Next-generation sequencing Pathogens Patients Pediatrics Physicians Prospective Studies Sequence Analysis, DNA Sequence Analysis, RNA Young Adult
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Beschreibung
Zusammenfassung:	In cases of suspected meningitis or encephalitis that were difficult to diagnose, metagenomic sequencing of CSF was used to attempt to determine the etiologic agent. Metagenomic sequencing was able to determine a likely pathologic agent that was clinically actionable in some cases.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1803396