Impact of timing to source control in patients with septic shock: A prospective multi-center observational study

Current guidelines recommend that rapid source control should be adopted in patients not >6–12 h after sepsis is diagnosed. However, evidence level of this guideline is not specified, and there is no previous study on patients with septic shock visiting the emergency department (ED). Therefore, w...

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Veröffentlicht in:	Journal of critical care 2019-10, Vol.53, p.176-182
Hauptverfasser:	Kim, Hongjung, Chung, Sung Phil, Choi, Sung-Hyuk, Kang, Gu Hyun, Shin, Tae Gun, Kim, Kyuseok, Park, Yoo Seok, Han, Kap Su, Choi, Han Sung, Suh, Gil Joon, Kim, Won Young, Lim, Tae Ho, Ko, Byuk Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Blood pressure Body temperature Catheters Critical care Data collection Emergency service Endoscopy Hospital Infection control Infections Liver diseases Lung diseases Mortality Observational studies Pancreas Sepsis Septic shock Surgery Urogenital system
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Zusammenfassung:	Current guidelines recommend that rapid source control should be adopted in patients not >6–12 h after sepsis is diagnosed. However, evidence level of this guideline is not specified, and there is no previous study on patients with septic shock visiting the emergency department (ED). Therefore, we aimed to assess the impact of rapid source control in patients with septic shock visiting the ED. In a prospective, observational, multicenter, registry-based study in 11 EDs, Cox proportional hazards model was used to assess the independent effect of source control and time to source control on 28-day mortality. Cox proportional hazard models revealed that 28-day mortality was significantly lower in patients who underwent source control (HR 0.538 (0.389–0.744), p
ISSN:	0883-9441 1557-8615
DOI:	10.1016/j.jcrc.2019.06.012