Brexanolone injection for post-partum depression treatment – Authors' reply

[...]we are grateful for the opportunity to clarify the potential role of other concomitant positive allosteric modulators of the γ-aminobutyric-acid A (GABAA) receptor. [...]most concomitant positive allosteric inhibitors used in our study were benzodiazepines, which do not share a common mechanism...

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Veröffentlicht in:The Lancet (British edition) 2019-08, Vol.394 (10196), p.380-380
Hauptverfasser: Meltzer-Brody, Samantha, Colquhoun, Helen, Doherty, James, Rubinow, David R, Kanes, Stephen
Format: Artikel
Sprache:eng
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Zusammenfassung:[...]we are grateful for the opportunity to clarify the potential role of other concomitant positive allosteric modulators of the γ-aminobutyric-acid A (GABAA) receptor. [...]most concomitant positive allosteric inhibitors used in our study were benzodiazepines, which do not share a common mechanism of action in post-partum depression as Tang and Parekh suggest. [...]please note that consumption of ethanol was not allowed during the infusion in the inpatient supervised study setting.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(19)30703-2