The impact of diagnostic wait time on the survival of patients with diffuse large B‐cell lymphoma: effect modification by the International Prognostic Index

Summary Despite the importance of a prompt diagnosis to improve cancer patients’ survival, little has been reported on diagnostic delay in diffuse large B‐cell lymphoma (DLBCL). A single‐centre, retrospective study was conducted to examine the association between diagnostic wait time (DWT), the inte...

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Veröffentlicht in:British journal of haematology 2019-10, Vol.187 (2), p.195-205
Hauptverfasser: Lee, Shin, Fujita, Kei, Negoro, Eiju, Morishita, Tetsuji, Yamauchi, Hideaki, Oiwa, Kana, Ueda, Takanori, Yamauchi, Takahiro
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Sprache:eng
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Zusammenfassung:Summary Despite the importance of a prompt diagnosis to improve cancer patients’ survival, little has been reported on diagnostic delay in diffuse large B‐cell lymphoma (DLBCL). A single‐centre, retrospective study was conducted to examine the association between diagnostic wait time (DWT), the interval from the initial hospital visit to diagnosis, and survival in patients with DLBCL. A total of 193 patients were enrolled from 2007 to 2017 in our institution. A covariate‐adjusted Cox proportional hazards model with restricted cubic spline was used to evaluate the impact of DWT on survival, with a subgroup analysis according to the International Prognostic Index (IPI). DWT was not associated with survival in the entire DLBCL population, but the impact of DWT on survival differed between IPI 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.16078