Hypermethylated Genes of MicroRNA in Ovarian Carcinoma: Metastasis Prediction Marker Systems

We identified a group of miRNA genes whose methylation is associated with ovarian cancer metastasis. Based on these data, new markers and the systems of markers predicting tumor dissemination were selected. Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we iden...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-05, Vol.167 (1), p.79-83
Hauptverfasser:	Filippova, E. A., Loginov, V. I., Burdennyi, A. M., Braga, E. A., Pronina, I. V., Kazubskaya, T. P., Kushlinskii, D. N., Utkin, D. O., Fridman, M. V., Khodyrev, D. S., Kushlinskii, N. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer genetics Carcinoma Cell Biology DNA methylation DNA Methylation - genetics Female Gene Expression Regulation, Neoplastic - genetics Genes Genetic aspects Humans Internal Medicine Laboratory Medicine Metastases Metastasis Methylation MicroRNA MicroRNAs MicroRNAs - genetics miRNA Oncology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Pathology Polymerase Chain Reaction Tumors
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Zusammenfassung:	We identified a group of miRNA genes whose methylation is associated with ovarian cancer metastasis. Based on these data, new markers and the systems of markers predicting tumor dissemination were selected. Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes ( MIR-124a-2 , MIR-127 , MIR-125b-1 , MIR-129-2 , MIR-137 , MIR-193a , MIR-203a , MIR-34b/c , MIR-130b , and MIR-1258 ) whose methylation is associated with tumor metastasis. The greatest association was established for 4 genes: MIR-137 , MIR-193a , MIR-34b/c , and MIR-130b ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04465-5