Secretome of Cultured Human Endothelial Cells in Simulated Microgravity

The secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and in modeled microgravity for 24 h was studied by chromatography-mass spectrometry. In the secretome of cells exposed to microgravity, we identified a group of microtubule proteins including many struc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-05, Vol.167 (1), p.35-38
Hauptverfasser:	Kashirina, D. N., Kononikhin, A. S., Larina, I. M., Buravkova, L. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Analysis Arrhythmia Biomedical and Life Sciences Biomedicine Cell Biology Chromatography Cytoskeleton Endothelial cells Endothelium G proteins Guanine nucleotide-binding protein Histamine Human Umbilical Vein Endothelial Cells - metabolism Humans Internal Medicine Laboratory Medicine Mass Spectrometry Mass spectroscopy Microgravity Microtubules Microtubules - metabolism Muscle proteins Pathology Proteins Regulatory proteins rho GTP-Binding Proteins - metabolism Secretome Signal Transduction - physiology Spectroscopy Umbilical vein Weightlessness Simulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and in modeled microgravity for 24 h was studied by chromatography-mass spectrometry. In the secretome of cells exposed to microgravity, we identified a group of microtubule proteins including many structural elements of microtubules and regulatory proteins interacting with Rho-GTPases. Hence, reorganization of actin cytoskeleton and microtubules induced by microgravity is under complex regulation mediated by Rho proteins.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04454-8