l ‑(−)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N‑Arylation of Nitrogen-Containing Heterocycles

l-(−)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

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Veröffentlicht in:Journal of organic chemistry 2019-06, Vol.84 (12), p.8160-8167
Hauptverfasser: Zhou, Qifan, Du, Fangyu, Chen, Yuanguang, Fu, Yang, Sun, Wenjiao, Wu, Ying, Chen, Guoliang
Format: Artikel
Sprache:eng
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Zusammenfassung:l-(−)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b00997