l ‑(−)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N‑Arylation of Nitrogen-Containing Heterocycles
l-(−)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.
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Veröffentlicht in: | Journal of organic chemistry 2019-06, Vol.84 (12), p.8160-8167 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | l-(−)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides. |
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ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/acs.joc.9b00997 |