Lambert-Eaton myasthenic syndrome and merkel cell carcinoma

Lambert-Eaton myasthenic syndrome (LEMS) is an antibody-mediated disorder of the neuromuscular junction that is most commonly diagnosed in association with small cell lung carcinoma (SCLC). Small cell lung carcinoma is histologically similar to the aggressive cutaneous neuroendocrine malignancy Merk...

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Veröffentlicht in:	Cutis (New York, N.Y.) N.Y.), 2019-05, Vol.103 (5), p.E19-E23
Hauptverfasser:	Nguyen, Nam D, Simmons, Daniel B, Bersabe, Adrian R, Duginski, Thomas M, Sladky, John H, Walton, Douglas, Will, Micah, Renshaw, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Merkel Cell - complications Carcinoma, Merkel Cell - secondary Humans Lambert-Eaton Myasthenic Syndrome - diagnosis Lambert-Eaton Myasthenic Syndrome - etiology Lymph Nodes - pathology Lymphatic Metastasis Male Middle Aged Neoplasms, Unknown Primary - complications Neoplasms, Unknown Primary - pathology Paraneoplastic Syndromes - etiology
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Zusammenfassung:	Lambert-Eaton myasthenic syndrome (LEMS) is an antibody-mediated disorder of the neuromuscular junction that is most commonly diagnosed in association with small cell lung carcinoma (SCLC). Small cell lung carcinoma is histologically similar to the aggressive cutaneous neuroendocrine malignancy Merkel cell carcinoma (MCC). We provide a full report and longitudinal clinical follow-up of a case of LEMS occurring with MCC. We also review the literature on paraneoplastic syndromes associated with MCC and other nonpulmonary small cell carcinomas.
ISSN:	2326-6929