Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins
It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease i...
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| Veröffentlicht in: | Doklady. Biochemistry and biophysics 2019-03, Vol.485 (1), p.132-134 |
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| container_title | Doklady. Biochemistry and biophysics |
| container_volume | 485 |
| creator | Lankin, V. Z. Sharapov, M. G. Goncharov, R. G. Tikhaze, A. K. Novoselov, V. I. |
| description | It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus. |
| doi_str_mv | 10.1134/S1607672919020157 |
| format | Article |
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A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S1607672919020157</identifier><identifier>PMID: 31201633</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Arteriosclerosis ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Diabetes mellitus ; Life Sciences ; Lipid peroxidation ; Lipids ; Molecular Biology ; Molecular modelling ; Peroxidase ; Peroxidation ; Pyruvaldehyde</subject><ispartof>Doklady. 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A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.</description><subject>Arteriosclerosis</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Diabetes mellitus</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Molecular Biology</subject><subject>Molecular modelling</subject><subject>Peroxidase</subject><subject>Peroxidation</subject><subject>Pyruvaldehyde</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwzAMhiMEYmPwA7igSly4FGKnS5rjNL4mTYAEnKs0TSFT146kRezfk30AEoiLbdmPX1svIcdAzwFYcvEInAouUIKkSGEodkg_tNKYUQm761rEq3mPHHg_owFCNtwnPQYB54z1yehOtZ1TVXRptXJ5Uy8rH03qV5vbNnowrvmwhfImGunWvtt2GTXltu1MEWLtD8leqSpvjrZ5QJ6vr57Gt_H0_mYyHk1jzQS2cVryHI02qGSRFMlQaU4x4UYgaCF1yvMklQDDArhBgWUpGFUaaQ48Fykt2YCcbXQXrnnrjG-zufXaVJWqTdP5DIMaJkwiBvT0FzprOleH71YUBSnEmoINpV3jvTNltnB2rtwyA5qt_M3--Bt2TrbKXT43xffGl6EBwA3gw6h-Me7n9P-qnzR-guc</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Lankin, V. 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| subjects | Arteriosclerosis Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Diabetes mellitus Life Sciences Lipid peroxidation Lipids Molecular Biology Molecular modelling Peroxidase Peroxidation Pyruvaldehyde |
| title | Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins |
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