Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins

Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins

It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease i...

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Veröffentlicht in:Doklady. Biochemistry and biophysics 2019-03, Vol.485 (1), p.132-134
Hauptverfasser: Lankin, V. Z., Sharapov, M. G., Goncharov, R. G., Tikhaze, A. K., Novoselov, V. I.
Format: Artikel
Sprache:eng
Schlagworte:
Arteriosclerosis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Diabetes mellitus
Life Sciences
Lipid peroxidation
Lipids
Molecular Biology
Molecular modelling
Peroxidase
Peroxidation
Pyruvaldehyde
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Zusammenfassung:It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672919020157