Renal cell carcinoma with (tubule) papillary architecture. Report of three cases and bibliographic review.

Update of clear cell (tubulo) papillary renal cell carcinoma. METHODS: We provide the only three cases described to date in our hospital. RESULTS: One of the new entities of epithelial renal tumors incorporated by the International Society of Urological Pathology (ISUP) in 2013 was the clear cell (tubulo) papillary renal cell carcinoma (RCCtpcc). Although initially was described under other nomenclatures, it was not until 2013 that it was clearly defined. CONCLUSION: The RCCtpcc is usually a low grade and stage subtype of epithelial RCC. It predominates in the sixth decade of life, although cases have already been described in children and young adults. It has a typical immunohistochemical pattern with positive CK7, vimentine, VT and smooth muscle antigen, and negative CD10. They usually have a low malignant potential.