Lipids lead the way

Lipids lead the way

Autophagy is a ‘self-eating’ recycling process that maintains cellular homeostasis. Autogramins were identified as small-molecule autophagy inhibitors that target the cholesterol transport protein GRAMD1A, revealing a role for cholesterol in autophagosome biogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:Nature chemical biology 2019-07, Vol.15 (7), p.653-654
1. Verfasser: Aldrich, Leslie N.
Format: Artikel
Sprache:eng
Schlagworte:
631/80/82
631/92/287
631/92/555
631/92/613
Autophagy
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cholesterol
Homeostasis
Lead
Lipids
News & Views
news-and-views
Phagocytosis
Protein transport
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Beschreibung
Zusammenfassung:Autophagy is a ‘self-eating’ recycling process that maintains cellular homeostasis. Autogramins were identified as small-molecule autophagy inhibitors that target the cholesterol transport protein GRAMD1A, revealing a role for cholesterol in autophagosome biogenesis.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-019-0309-3