A pH-sensitive near-infrared fluorescent probe with alkaline pKa for chronic wound monitoring in diabetic mice

A pH-sensitive near-infrared fluorescent probe with alkaline pKa for chronic wound monitoring in diabetic mice

A pH-sensitive near-infrared fluorescent probe with alkaline pKa, AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wound...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-06, Vol.55 (51), p.7374-7377
Hauptverfasser: Hengtang Mai, Wang, Yu, Li, Shuang, Jia, Ruizhen, Li, Sixian, Peng, Qian, Xie, Yan, Hu, Xiang, Wu, Song
Format: Artikel
Sprache:eng
Schlagworte:
Alkalizing
Cyanine dyes
Diabetes
Fluorescent indicators
Hydrazines
NMR
Nuclear magnetic resonance
Rodents
Selectivity
Toxicity
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Beschreibung
Zusammenfassung:A pH-sensitive near-infrared fluorescent probe with alkaline pKa, AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wounds in diabetic mice.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc02289a