Two types of fibroblast drive arthritis

Two types of fibroblast drive arthritis

Fibroblast cells promote the development of rheumatoid arthritis. The finding that two distinct fibroblast populations affect different aspects of the disease in mice has implications for efforts to develop clinical treatments. Inflammation and bone erosion are caused by different cell populations.

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Veröffentlicht in:Nature (London) 2019-06, Vol.570 (7760), p.169-170
1. Verfasser: Wynn, Thomas A.
Format: Artikel
Sprache:eng
Schlagworte:
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Arthritis
Autoimmune diseases
Biocompatibility
Biomedical materials
Cartilage
Cartilage diseases
Cytokines
Disease
Erosion
Fibroblasts
Gene expression
Immune system
Immunology
Inflammation
News And Views
Osteoarthritis
Proteins
Rheumatoid arthritis
Rheumatoid factor
Ribonucleic acid
RNA
Synovial membrane
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Beschreibung
Zusammenfassung:Fibroblast cells promote the development of rheumatoid arthritis. The finding that two distinct fibroblast populations affect different aspects of the disease in mice has implications for efforts to develop clinical treatments. Inflammation and bone erosion are caused by different cell populations.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-019-01594-9