Prognostic value of the FUT family in acute myeloid leukemia

Genetic abnormalities are more frequently viewed as prognostic markers in acute myeloid leukemia (AML) in recent years. Fucosylation, catalyzed by fucosyltransferases (FUTs), is a post-translational modification that widely exists in cancer cells. However, the expression and clinical implication of...

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Veröffentlicht in:	Cancer gene therapy 2020-02, Vol.27 (1-2), p.70-80
Hauptverfasser:	Dai, Yifeng, Cheng, Zhiheng, Pang, Yifan, Jiao, Yang, Qian, Tingting, Quan, Liang, Cui, Longzhen, Liu, Yan, Si, Chaozeng, Chen, Jinghong, Ye, Xu, Chen, Jingqi, Shi, Jinlong, Wu, Depei, Zhang, Xinyou, Fu, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283 692/53 Acute myeloid leukemia Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomedical and Life Sciences Biomedicine Bone Marrow - pathology Cancer Chemotherapy Disease-Free Survival Female Follow-Up Studies Fucosyltransferases - genetics Gene Expression Gene Expression Regulation, Leukemic Gene Therapy Genetic aspects Genomes Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Kaplan-Meier Estimate Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Male Medical prognosis Medical research Medicine, Experimental Middle Aged Multivariate analysis Myeloid leukemia Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - genetics Post-translation Prognosis Risk Factors Stem cell transplantation Transplantation Transplantation, Homologous Young Adult
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Zusammenfassung:	Genetic abnormalities are more frequently viewed as prognostic markers in acute myeloid leukemia (AML) in recent years. Fucosylation, catalyzed by fucosyltransferases (FUTs), is a post-translational modification that widely exists in cancer cells. However, the expression and clinical implication of the FUT family ( FUT1-11 ) in AML has not been investigated. From the Cancer Genome Atlas database, a total of 155 AML patients with complete clinical characteristics and FUT1-11 expression data were included in our study. In patients who received chemotherapy alone showed that high expression levels of FUT3 , FUT6 , and FUT7 had adverse effects on event-free survival (EFS) and overall survival (OS) (all P
ISSN:	0929-1903 1476-5500
DOI:	10.1038/s41417-019-0115-9