Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter

Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter

Failure of autophagy induction results in the accumulation of abnormal mitochondria to cause neurodegenerative diseases. Artificial autophagy activation via the mitochondrial delivery of polyrotaxane with autophagy induced activity is achieved using a MITO-Porter, a nanodevice for mitochondrial deli...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-06, Vol.55 (50), p.7203-7206
Hauptverfasser: Yamada, Yuma, Daikuhara, Shinnosuke, Tamura, Atsushi, Nishida, Kei, Yui, Nobuhiko, Harashima, Hideyoshi
Format: Artikel
Sprache:eng
Schlagworte:
Autophagy
Cyclodextrins
Mitochondria
Nanotechnology devices
Neurological diseases
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Zusammenfassung:Failure of autophagy induction results in the accumulation of abnormal mitochondria to cause neurodegenerative diseases. Artificial autophagy activation via the mitochondrial delivery of polyrotaxane with autophagy induced activity is achieved using a MITO-Porter, a nanodevice for mitochondrial delivery. This strategy can be applied to innovative research and therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc03272j