Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives

Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The p-chlorophenyl derivatives showed antiviral activity in a range of micromolar concentration. [Display omitted] •New D-xilo and D-ribo imidazothiazoles derivatives were synthesized from d-glucose.•The nitro compounds only could be obtained at highest temperatures.•Heterocyclization gave better yields when N,N-dimethylformamide is used as solvents.