Integrated analysis of clinical significance and functional involvement of microRNAs in hepatocellular carcinoma

Integrated analysis of clinical significance and functional involvement of microRNAs in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. To explore the potential prognosis‐associated microRNAs (miRNAs) for HCC patients, we performed integrated analyses on the miRNA expression profiles from The Cancer Genome Atlas project. Genome‐wide overall survival (...

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Veröffentlicht in:Journal of cellular physiology 2019-12, Vol.234 (12), p.23581-23595
Hauptverfasser: Qin, Li, Huang, Jian, Wang, Guodong, Huang, Jinxin, Wu, Xintian, Li, Jinzhuan, Yi, Weili, Qin, Fuhui, Huang, Dongning
Format: Artikel
Sprache:eng
Schlagworte:
1-Phosphatidylinositol 3-kinase
AKT protein
biomarker
Biomarkers
Cancer
Clinical significance
Gene expression
Genomes
Hazards
Hepatocellular carcinoma
Liver cancer
Medical prognosis
microRNA
MicroRNAs
miRNA
overall survival
progression‐free survival
Regression analysis
Signal transduction
Survival
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Zusammenfassung:Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. To explore the potential prognosis‐associated microRNAs (miRNAs) for HCC patients, we performed integrated analyses on the miRNA expression profiles from The Cancer Genome Atlas project. Genome‐wide overall survival (OS)‐ and progression‐free survival (PFS)‐associated miRNA screening were performed by multivariate Cox proportional hazards regression analyses. A five‐miRNA expression signature (miR‐148a, miR‐3677‐3p, miR‐744*, miR‐210, and miR‐3613‐5p) was identified as an indicator for HCC OS (p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28927