Empagliflozin improves primary haemodynamic parameters and attenuates the development of atherosclerosis in high fat diet fed APOE knockout mice

The effects of long-term treatment with empagliflozin on biochemical and immunohistochemical markers related to atherosclerosis and atherosclerosis development in the aorta of apolipoprotein E knockout [Apo-E (−/−)] mice were evaluated in this study. Empagliflozin-treated mice had lower total choles...

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Veröffentlicht in:	Molecular and cellular endocrinology 2019-08, Vol.494, p.110487-110487, Article 110487
Hauptverfasser:	Dimitriadis, Georgios K., Nasiri-Ansari, Narjes, Agrogiannis, Georgios, Kostakis, Ioannis D., Randeva, Manpal S., Nikiteas, Nikolaos, Patel, Vanlata H., Kaltsas, Gregory, Papavassiliou, Athanasios G., Randeva, Harpal S., Kassi, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals APOE knockout mice Atherosclerosis Atherosclerosis - blood Atherosclerosis - drug therapy Atherosclerosis - pathology Atherosclerosis - physiopathology Benzhydryl Compounds - administration & dosage Benzhydryl Compounds - pharmacology Benzhydryl Compounds - therapeutic use Blood Glucose - metabolism Blood Pressure - drug effects Diastole - drug effects Diet, High-Fat Empagliflozin Fasting - blood Glucosides - administration & dosage Glucosides - pharmacology Glucosides - therapeutic use Heart Rate - drug effects Hemodynamics - drug effects Inflammation Lipids - blood Metalloproteases - metabolism Mice, Inbred C57BL Mice, Knockout, ApoE Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - physiopathology RNA, Messenger - genetics RNA, Messenger - metabolism SGLT2i
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Zusammenfassung:	The effects of long-term treatment with empagliflozin on biochemical and immunohistochemical markers related to atherosclerosis and atherosclerosis development in the aorta of apolipoprotein E knockout [Apo-E (−/−)] mice were evaluated in this study. Empagliflozin-treated mice had lower total cholesterol (P
ISSN:	0303-7207 1872-8057
DOI:	10.1016/j.mce.2019.110487