GCV/VCVG prophylaxis against CMV DNAemia in pediatric renal transplant patients: A systematic review and meta‐analysis

GCV/VCVG prophylaxis against CMV DNAemia in pediatric renal transplant patients: A systematic review and meta‐analysis

CMV disease continues to stand as a significant threat to the longevity of renal transplants in children. More pediatric recipients are CMV‐negative with CMV‐positive donor serologies resulting in a HR mismatch. The length of prophylaxis with GCV or VGCV required to optimally prevent recurrence of C...

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Veröffentlicht in:Pediatric transplantation 2019-09, Vol.23 (6), p.e13514-n/a
Hauptverfasser: Chatani, Brandon, Glaberson, Wendy, Nemeth, Zsuzsanna, Tamariz, Leonardo, Gonzalez, Ivan A.
Format: Artikel
Sprache:eng
Schlagworte:
Case reports
cytomegalovirus
infectious risk
Kidney transplantation
Kidney transplants
Meta-analysis
pediatric kidney transplant
pediatric kidney transplantation
pediatric transplantation
Pediatrics
Prophylaxis
Statistical analysis
Studies
Transplants & implants
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Zusammenfassung:CMV disease continues to stand as a significant threat to the longevity of renal transplants in children. More pediatric recipients are CMV‐negative with CMV‐positive donor serologies resulting in a HR mismatch. The length of prophylaxis with GCV or VGCV required to optimally prevent recurrence of CMVDNAemia remains unknown. This study is a meta‐analysis comparing GCV/VGCV prophylaxis regimens provided for
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13514